Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed…

Ninety percent of cancer-related mortality is caused by metastasis. Current cancer treatments can control many primary tumors but rarely stop the metastatic spread. Accumulating evidence demonstrates that miRNAs are involved in cancer initiation and…

Invasion and metastasis is the hallmark of tumour malignancy. Some aspects of invasion and metastasis with potential implications for tumour therapy are reviewed: the value of laboratory models; the acquisition of invasiveness and metastatic…

MicroRNAs are small non-coding RNA molecules that control expression of target genes. Previous studies showed that microRNA-107 (miR-107) is overexpressed in gastric cancer tissues compared with the matched normal tissues. However, it remains…

MiRNAs have been shown to function as regulatory molecules and to play an important role in cancer progression. Very little is currently known about the increasing invasion and metastasis of breast cancer due to the loss of expressive levels of…

In this paper we present two types of mathematical model which describe the invasion of host tissue by tumour cells. In the models, we focus on three key variables implicated in the invasion process, namely, tumour cells, host tissue (extracellular…

The immune system plays a pivotal role in tumor establishment. However, the role of T-lymphocytes within the tumor microenvironment as major cellular component of the adaptive effector immune response and their counterpart, regulatory T cells…

Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new…

This review presents the evidence for the hypothesis that dietary linoleic acid and its metabolic derivative arachidonic acid enhance the metastatic process in breast cancer. Key biochemical events are eicosanoid biosynthesis and protein kinase C…

We recently identified and cloned novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a great sequence homology with the Alzheimer's disease related neural protein synuclein (SNC); thus, it was also named…