Papers

DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available,…

RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

The two most commonly used methods to analyze data from real-time, quantitative PCR experiments are absolute quantification and relative quantification. Absolute quantification determines the input copy number, usually by relating the PCR signal to…

Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform,…

Ten years after the publication of the position paper The hallmarks of cancer (Hanahan and Weinberg Cell 100:5770, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in…

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include…

In this article, we attempt to distinguish between the properties of moderator and mediator variables at a number of levels. First, we seek to make theorists and researchers aware of the importance of not using the terms moderator and mediator…

We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations. We assume a model in which there are K populations (where K may be unknown), each of which is…

Insights into conducting research and the writing of scientific papers are given by Prof. Whitesides in this short essay. The manuscript and its guidelines has been circulated within the Whitesides' research group since 1989.

Error bars commonly appear in figures in publications, but experimental biologists are often unsure how they should be used and interpreted. In this article we illustrate some basic features of error bars and explain how they can help communicate…

The tutorial starts with an overview of the concepts of VC dimension and structural risk minimization. We then describe linear Support Vector Machines (SVMs) for separable and non-separable data, working through a non-trivial example in detail. We…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

Computing as you know it is about to change, your applications and documents are going to move from the desktop into the cloud. I'm talking about cloud computing, where applications and files are hosted on a "cloud" consisting of thousands of…

We have designed and implemented the Google File System, a scalable distributed file system for large distributed data-intensive applications. It provides fault tolerance while running on inexpensive commodity hardware, and it delivers high…

Provided certain obstacles are overcome, we believe Cloud Computing has the potential to transform a large part of the IT industry, making software even more attractive as a service and shaping the way IT hardware is designed and purchased.…

The dynamic capabilities framework analyzes the sources and methods of wealth creation and capture by private enterprise firms operating in environments of rapid technological change. The competitive advantage of firms is seen as resting on…

There is now ample evidence of the ecological impacts of recent climate change, from polar terrestrial to tropical marine environments. The responses of both flora and fauna span an array of ecosystems and organizational hierarchies, from the…

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides…

India is now a nuclear weapon state, irrespective of whether the Western nuclear powers recognise it as such or not, shackled as they are by the narrow confines of the nuclear Non-Proliferation Treaty (NPT) definition of a nuclear weapon state. In…

The purpose of this study is to investigate the generic identification of Psalm 78 as political accession justification for the Davidic dynasty. Typically attempts to identify the genre of the psalm are based on data and/or characteristics found in…

The purpose of this dissertation was to examine the Psalms 49-51 corpus to determine whether the three psalms exhibit evidence of intentional arrangement. Psalm 50 is the only psalm of Asaph not connected in sequence with the other Asaphite psalms.…

In mid-2006, the Indonesian government announced a plan to buildnuclear power plants geared towards meeting soaring demands for energy in thecountry. After prolonged procrastination, the government is determined that time isripe for Indonesia to go…

We propose a way in which Pothos & Busemeyer (P&B) could strengthen their position. Taking a dynamic stance, we consider cognitive tests as functions that transfer a given input state into the state after testing. Under very general conditions, it…

In mid-2006, the Indonesian government announced a plan to buildnuclear power plants geared towards meeting soaring demands for energy in thecountry. After prolonged procrastination, the government is determined that time isripe for Indonesia to go…

This article examines gender-based differences in the New Zealand public's view of defense and nuclear issues. During the last few years defense and nuclear concerns have become important political issues in New Zealand. Indeed, in 1984 the New…

India is now a nuclear weapon state, irrespective of whether the Western nuclear powers recognise it as such or not, shackled as they are by the narrow confines of the nuclear Non-Proliferation Treaty (NPT) definition of a nuclear weapon state. In…

The size of data collected by qualitative research methods is extremely large as compare to traditional quantitative data collections, and making sense interviews and field notes can beoverwhelming. Often organizing and analyzing the data can appear…

Low dimensional spin-frac12 systems with display very innovative features, driven by strong quantum fluctuations. In particular, geometrical effects or competing magnetic interactions can give rise to the formation of a spin gap between the singlet…

Bechtle on the soul as harmony between Phaedo and Timaeus. Bechtle argues that the bridge between material harmony and immortal soul is made through the intermediary position of mathematics.

Nmental crimes program in the United States has entered its third decade, yet questions remain about what makes an environmental violation criminal. Our environmental laws make only limited distinctions between criminal and civil liability, so…

In this essay, I meditate on the riddle of Emersonian transparency, mainly as it appears in Nature. Not pretending to solve the enigma, I offer a fresh perspective from which to study its difficulties. This context is Emerson's interest in crystal…

Comments on J. Rychlak's (see record 1993-43676-001) descriptions of irreducible grounding epistemological-ontological positions that complement or compensate for each other. Some aspects of Rychlak's groundings and their application are unclear,…

Contemporary choral music in general and George Rochberg's in particular present challenges to the conductor well beyond the traditional repertoire including complex harmonies and rhythms, tone clusters, sprechstimme , and unconventional notation.…

Contemporary choral music in general and George Rochberg's in particular present challenges to the conductor well beyond the traditional repertoire including complex harmonies and rhythms, tone clusters, sprechstimme , and unconventional notation.…

We reported that genistein, a soybean isoflavone, prevents bone loss caused by estrogen deficiency, without undesirable effects on the uterus. In this study, we examined cooperative effects of genistein administration and running exercise on bone…

Este estudo realizou um teste experimental em que os autores investigaram três efeitos que afetam a percepção de preços por parte dos consumidores. O estudo investigou a prática, cada vez mais comum no ambiente varejista brasileiro, da comparação de…

Este estudo realizou um teste experimental em que os autores investigaram três efeitos que afetam a percepção de preços por parte dos consumidores. O estudo investigou a prática, cada vez mais comum no ambiente varejista brasileiro, da comparação de…

Characteristics of cloud overlap over Eastern Asia are analyzed using a three-year dataset (2007-2009) from the cloud observing satellite CloudSat. Decorrelation depth Lcf is retrieved, which represents cloud overlap characteristics in the…