Papers

DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available,…

Ten years after the publication of the position paper The hallmarks of cancer (Hanahan and Weinberg Cell 100:5770, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

The two most commonly used methods to analyze data from real-time, quantitative PCR experiments are absolute quantification and relative quantification. Absolute quantification determines the input copy number, usually by relating the PCR signal to…

Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform,…

In this article, we attempt to distinguish between the properties of moderator and mediator variables at a number of levels. First, we seek to make theorists and researchers aware of the importance of not using the terms moderator and mediator…

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include…

There is now ample evidence of the ecological impacts of recent climate change, from polar terrestrial to tropical marine environments. The responses of both flora and fauna span an array of ecosystems and organizational hierarchies, from the…

RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a…

We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations. We assume a model in which there are K populations (where K may be unknown), each of which is…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

Computing as you know it is about to change, your applications and documents are going to move from the desktop into the cloud. I'm talking about cloud computing, where applications and files are hosted on a "cloud" consisting of thousands of…

The dynamic capabilities framework analyzes the sources and methods of wealth creation and capture by private enterprise firms operating in environments of rapid technological change. The competitive advantage of firms is seen as resting on…

Insights into conducting research and the writing of scientific papers are given by Prof. Whitesides in this short essay. The manuscript and its guidelines has been circulated within the Whitesides' research group since 1989.

We have designed and implemented the Google File System, a scalable distributed file system for large distributed data-intensive applications. It provides fault tolerance while running on inexpensive commodity hardware, and it delivers high…

Provided certain obstacles are overcome, we believe Cloud Computing has the potential to transform a large part of the IT industry, making software even more attractive as a service and shaping the way IT hardware is designed and purchased.…

The tutorial starts with an overview of the concepts of VC dimension and structural risk minimization. We then describe linear Support Vector Machines (SVMs) for separable and non-separable data, working through a non-trivial example in detail. We…

Error bars commonly appear in figures in publications, but experimental biologists are often unsure how they should be used and interpreted. In this article we illustrate some basic features of error bars and explain how they can help communicate…

We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides…

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

Siderite and calcite are the two forms of carbonate commonly associated with Permian Australian coals. The former occurs as disseminated spherulites and is a product of the early post-depositional environment. Isotopic measurements show that the CO…

Based on the principle of fuzzy control and neuron control, an intelligent controller is applied successfully to a system of low voltage and high power ammonia compressor. By regulating speed with an inverter, the power economizing technique for the…

In the nematode Caenorhabditis elegans, the heat shock response (HSR) is regulated at the organismal level by a network of thermosensory neurons that senses elevated temperatures and activates the HSR in remote tissues. Which neuronal receptors are…

Extensive discussions of practical wisdom are relatively rare in the philosophical literature these days. This is strange given the theoretical and practical importance of wisdom and, indeed, the etymology of the word "philosophy". In this paper, we…

Summary form only. While the traditional planning problem can be viewed as a temporal reasoning problem in the abstract, most planning algorithms use specialized constrained representations that are only useful for the planning task. In the TRIPS…

Aiming at the ubiquitous network development and robust space location problem, a location configuration model based on space MIMO array and beam beacon scanning is proposed in this paper. The location algorithm and technique fusion of this model…

We present the articles of Hipólito Unanue y Pavón (1755-1833) -precursor of the Independence of Peru- published in the illustrated and well-known newspaper called "Mercurio Peruano" (1791-1794). A clear influence of the Enlightenment is noticed in…

To solve the problem that water quality of sewage disposal process (such as BOD) is difficulty to measure on-line, meanwhile considering the characteristics of sewage disposal process which is related with time. A soft sensor method for water…

Report profiles the Mapping the Republic of Letters project, which originated at Stanford University in 2008 with a three-year-university grant and subsequently received a National Endowment for the Humanities grant. Stanford scholars and…

The importance of early life events in the development of metabolic diseases is well recognized. Early postnatal environment, including nutrition, is key to future health, and this is particularly true for preterm infants. It is important that these…

Symptomatic remission has been defined as a complete or near-complete absence of symptoms. Just as the distinction between remitters and nonremitters among treatment responders has clinical significance, the distinction between a complete and…

This article features the presentation of electronic-reader devices at the Frankfurt Book Fair in Germany in October 2010. A number of publishing executives discussed electronic books and the condition of publishing in general. They also raised…

Grid partition of geometry model in finite element analysis results in massive redundant geometry points, comprising of point cloud, which is tend to be rendered in various aspects to analyze result in the post-processing. In order to deal with…

Nanotechnology requires very low vibration levels in buildings. In order to ensure the serviceability engineers have to design appropriate buildings. Realistic vibration criteria will be presented for nanotechnology research and production. Often…

The view that the fetus' potential for human consciousness confers upon it the right to life has been widely criticised on the basis that the notion of potentiality is so vague as to be meaningless, and on the basis that actual rights cannot be…

"Big" decisions are defined as discontinuous, abrupt, and unique, in contrast to "little" decisions, which are marginal, commensurable, and additive. We can model big decisions, as well as a wider range of little decisions, if we enlarge our notion…

A novel SOA-based Architecture for large-scale deployment and integration of RFID devices at the edges of network was proposed, which implemented device agnostic to upstream layers and Seamless connectivity between the heterogeneous systems. The…

There are twice as many suicides as homicides in the United States, and the suicide rate is rising. Suicides increased 12% between 1999 and 2009. Mental health professionals often treat suicidal patients, and suicide occurs even among patients who…

Velocity and size measurements of ejecta derived from impacts of railgun- launched projectiles into 10 mm thick gabbro tiles are examined. Fragmentation of the target and the ejecta velocity field are found to be governed by Hertzian fracture and…

Hand-selected lithotypes of a Polish subbituminous coal were examined using organic-geochemical methods and microscopy. The random reflectance of the vitrinite was determined to be 0.52%. Chemical analysis of solvent extracts showed that in this…