We tested the hypothesis that single nucleotide polymorphisms (SNPs) within genes of the NF-κB pathway are associated with altered clinical outcome of septic shock patients. We genotyped 59 SNPs in the NF-κB pathway in a discovery cohort of septic…
Papers in Chemical Engineering
Chemical Engineering papers in Engineering, A
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This paper reports a method for fabricating a 100 nm scale heater-thermometer into a silicon microcantilever based on contact photolithography and a controlled annealing process. The heater is formed during a photolithography process that can…
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A rapid microcentrifuge-based method is described for preparation of Pseudomonas aeruginosa electrocompetent cells with up to 10,000-fold increased transformation efficiencies over existing procedures. This increased efficiency now enables the use…
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A 128-channel receive-only array coil is described and tested for cardiac imaging at 3T. The coil is closely contoured to the body with a "clam-shell" geometry with 68 posterior and 60 anterior elements, each 75 mm in diameter, and arranged in a…
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This paper presents the major design criteria and features for the 13.3 million gallons per day (MGD) seawater reverse osmosis (RO) desalination plant that is currently under construction in Madinat Yanbu Al-Sinaiyah, Yanbu Industrial City, in the…
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Rat hearts were perfused with mixtures of 3-(13)Cpyruvate and 3-(13)Clactate (to alter cytosolic redox) at low (0.5 mM) or high (2.5 mM) Ca(2+) concentrations to alter contractility. Hearts were frozen at various times after exposure to these…
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Pyruvate carboxylation is important in energy metabolism. However, accurate quantification of pyruvate carboxylation with NMR remains to be demonstrated. In this study, a 13C isotopomer model for citrate acid cycle was developed and applied to the…
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Measurement of local myocardial O(2) consumption (VO(2)) has been problematic but is needed to investigate the heterogeneity of aerobic metabolism. The goal of the present investigation was to develop a method to measure local VO(2) using small…
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This paper presents a 13C CP/MAS NMR study of the melanin pigments obtained through natural and synthetic origins: sepia-melanin from squid ink and three synthetic 5,6-dihydroxyindole-melanins prepared using different non-enzymatic oxidation…
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MR imaging has become an important technique for the diagnosis of breast diseases. Crucial for the image quality is the performance of the RF coil. In this study a 16 channel breast phased array coil for 1.5T and 3T each is presented. The coil size…
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With this study we present a novel 16 channel array-coil with a transmitter coil for investigations on rats which is optimized for rat abdominal imaging. Decoupling electronics, phase shifters and preamplifiers are included in the coil. The…
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A 16 channel transmit/receive array based on decoupled transmission line elements for 9.4T is presented. The coils slim housing design along with shortened resonance elements in front of the eyes supports task presentation within a Head Gradient…
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In this work we describe a single channel transmit coil and 8-channel receive array for in vivo rodent imaging on a 7 T whole-body scanner. The coil system consists of a linearly polarized, actively detuned birdcage coil for transmit and a…
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The paper reports an investigation on the transient evolution of diesel flames in terms of fuel air mixing, spray penetration and combustion rate. A one-dimensional (1D) spray model, which was previously validated for inert diesel sprays, is…
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The anterior cingulate cortex (ACC) has been implicated in the pathophysiology of borderline personality disorder (BPD). Several studies have reported anatomical and functional abnormalities in this region in BPD patients. To date only one other…
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Senescence, which is a permanent cell cycle arrest, is thought to act as a fail-safe mechanism to prevent the transformation of cells into malignant phenotypes; as a tumour suppressing mechanism it shares conceptual and therapeutic similarities with…
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Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of beta cells in the islets of Langerhans. Low expression of antioxidants and a predilection to produce nitric oxide (NO) have been shown to…
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Regulatory T cells (T(reg) cells) suppress autoreactive immune responses and limit the efficacy of tumor vaccines; however, it remains a challenge to selectively eliminate or inhibit T(reg) cells. In this study, the zinc-finger A20, a negative…
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Regulatory T cells (T(reg) cells) suppress autoreactive immune responses and limit the efficacy of tumor vaccines; however, it remains a challenge to selectively eliminate or inhibit T(reg) cells. In this study, the zinc-finger A20, a negative…
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Many B cell cancers are characterized in part by the dysregulation of the NF-κB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-κB inhibitor A20, in Hodgkin lymphomas and primary mediastinal…
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