We tested the hypothesis that single nucleotide polymorphisms (SNPs) within genes of the NF-κB pathway are associated with altered clinical outcome of septic shock patients. We genotyped 59 SNPs in the NF-κB pathway in a discovery cohort of septic…
Papers in Statistics
Statistics papers in Mathematics, A
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Although considerable attention has been paid to the record of temperature change over the last few centuries, the range and rate of change of atmospheric circulation and hydrology remain elusive. Here, eight latitudinally well-distributed…
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Acquired immune deficiency syndrome (AIDS), malaria and tuberculosis collectively cause more than five million deaths per year, but have nonetheless eluded conventional vaccine development; for this reason they represent one of the major global…
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This study documents the detrimental effects of human recreation on the North American wood turtle (Clemmys insculpta) in Connecticut. We chronicled the dynamics of two allopatric wood turtle populations in a protected southern New England wildlife…
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Introduction Early screening for hearing loss is currently recognized as an international healthcare standard. In Cuba, such a program was initiated in the capital, Havana, in 1983 and scaled up to national coverage in 1991. Objective Review the…
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This paper explores the theoretical developments and subsequent uptake of sequential methodology in clinical studies in the 25 years since Statistics in Medicine was launched. The review examines the contributions which have been made to all four…
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At present, there is no method available to predict response to farnesyltransferase inhibitors (FTIs). We analyzed gene expression profiles from the bone marrow of patients from a phase 2 study of the FTI tipifarnib in older adults with previously…
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1 The Bibury long-term data set contains information on annual fluctuations in the abundance of over 100 grasses and forbs in roadside verge vegetation over the period from 1958 to the present. Monitoring has been carried out every July by the same…
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A 3D architectural and process-based model of maize development was implemented on the basis of the L-system software Graphtal, interfaced with physical models computing microclimate distributed on the 3D canopy structure. In a first step, we…
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The aim of this study was to analyse whether Physical Activity Index (PAI), Physical Fitness, Screen Time (watching TV and computer use), Socio-economic Status and Commuting to School made a significant contribution to longitudinal changes in Body…
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AIM: To analyse whether changes in physical activity index (PAI), screen time (ST: television, computer) and body mass index (BMI) made a contribution to longitudinal changes in fitness of children and adolescents. Additionally, we analysed the…
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BACKGROUND: Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy. METHODS: In this randomized, double-blind…
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BACKGROUND: The calcipotriol/betamethasone dipropionate two-compound product Pharma A/S, Ballerup, Denmark) has been shown to be safe and effective in the treatment of psoriasis for up to 8 weeks. As psoriasis is a chronic disease, long-term…
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The incidence of anaerobic bacteraemia was studied retrospectively over 62 months at Mont-Godinne University Hospital, Yvoir, Belgium. The distribution of organisms, clinical presentations, choice of antimicrobial therapy and clinical outcome were…
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Adeno-associated virus mediates correction of genetic mutations in mouse liver.
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Transcriptional regulatory circuits provide only a fraction of the signaling pathways and regulatory mechanisms that control the bacterial cell cycle. The CtrA regulatory network, important in control of the Caulobacter cell cycle, illustrates the…
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An Avian BioAccumulation Model (ABAM) of persistent organic pollutant (POP) uptake and elimination in adult life-stage of birds was validated by simulation of concentrations of DDE, dieldrin, mirex, and HCB in herring gull eggs in Lake Ontario for…
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For two and higher dimensional kernel regression, currently available bandwidth selection procedures are based on cross-validation or related penalizing ideas. However, these techniques have been shown to suffer from high sample variability and, in…
Papers in associated sub-disciplines
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