Principal component analysis (PCA) is a widely used statistical technique for unsupervised dimension reduction. K-means clustering is a commonly used data clustering for performing unsupervised learning tasks. Here we prove that principal components…
Papers in Medicine
Miscellaneous papers in Medicine, K
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In recent years there has been a growing interest in the study of sparse representation of signals. Using an overcomplete dictionary that contains prototype signal-atoms, signals are described by sparse linear combinations of these atoms.…
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By averaging the current that passes through cell-attached patches on beating heart cells, while measuring action potentials with a whole-cell electrode, we were able to study K channels during beating. In 7-d chick ventricle in 1.3 mM K…
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Ionic fluxes are thought to be involved in mediating the proliferation of peripheral blood lymphocytes (PBLs) in response to mitogenic substances. Among the earliest events occurring after the addition of mitogen to cultured lymphocytes are changes…
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Purpose - Seeks to provide practitioners of management with a sense of the importance of strategically leveraging social responsibility in that it provides a sustainable competitive advantage and requires a culture that can successfully execute a…
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Molecular dynamics simulations of a bacterial potassium channel (KcsA) embedded in a phospholipid bilayer reveal significant differences in interactions of the selectivity filter with K(+) compared with Na(+) ions. K(+) ions and water molecules…
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Hyperkalemia complicates trimethoprim-sulfamethoxazole (TMP-SMX) therapy in over 20% of HIV-infected patients. TMP is a heterocyclic weak base, similar to amiloride, a "K(+)-sparing" diuretic and Na+ channel blocker. Apical TMP is known to inhibit…
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The effects of the K(v) 7 channel modulators retigabine (opener) and XE991 (blocker) on rat bladder function were investigated ex vivo and in vivo to assess the potential of K(v) 7 openers for the treatment of overactive bladder. In organ bath…
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This paper presents a generalized version of the conventional k-means clustering algorithm Proceedings of 5th Berkeley Symposium on Mathematical Statistics and Probability, 1, University of California Press, Berkeley, 1967, p. 281. Not only is this…
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The effects of a variety of antiproliferative agents on voltage-dependent K+ channel function in cortical oligodendrocyte progenitor (O-2A) cells were studied. Previously, we had shown that glutamate receptor activation reversibly inhibited O-2A…
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K+ channels are a most diverse class of ion channels in the plasma membrane and are distributed widely throughout a variety of cells including cancer cells. Evidence has been accumulating from fundamental studies indicating that tumour cells possess…
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Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two…
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Sensory transduction in the cochlea and the vestibular labyrinth depends on the cycling of K+. In the cochlea, endolymphatic K+ flows into the sensory hair cells via the apical transduction channel and is released from the hair cells into perilymph…
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Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for assessing mitochondrial function, particularly in the context of cell fate determination in biological and biomedical research. However, valid interpretation…
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Sperm of salmonid fishes are quiescent in the presence of millimolar concentrations of extracellular K+, but motility initiation occurs when sperm are suspended in K+-free medium. In this study, glycerol (CH2OHCHOHCH2OH) treatment of intact sperm in…
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BACKGROUND: Endothelial dysfunction contributes to ischemia-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC). IPC may involve activation of ATP-sensitive potassium channels (K(ATP)). We determined whether modulation of…
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Evoked cortical responses to two kinds of auditory stimuli (rare and frequent) were analyzed to determine whether or not a K-complex evoked in stage 2 of NREM sleep is accompanied by some endogenous cognitive components of the event-related…
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This review summarises data gathered on the KC phenomenon over the past 70 yr. The following issues are discussed: definitions, morphology and topography of KC, the regular participation in NREM sleep, elicitability features of evoked KC, autonomic…
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OBJECTIVE: To examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). METHODS: Prolonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman…
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After passage through matter, the energy spectrum of a polychromatic beam of x-rays contains valuable information about the elemental composition of the absorber. Conventional x-ray systems or x-ray computed tomography (CT) systems, equipped with…
Papers in associated sub-disciplines
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