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Papers in Medicine

Miscellaneous papers in Medicine, K

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Papers 1 - 20 of 3,032 in Miscellaneous, K
  1. Purpose - Seeks to provide practitioners of management with a sense of the importance of strategically leveraging social responsibility in that it provides a sustainable competitive advantage and requires a culture that can successfully execute a…
  2. Missing data is a common drawback in many real-life pattern classification scenarios. One of the most popular solutions is missing data imputation by the K nearest neighbours (K NN) algorithm. In this article, we propose a novel K NN imputation…
  3. The effects of a variety of antiproliferative agents on voltage-dependent K+ channel function in cortical oligodendrocyte progenitor (O-2A) cells were studied. Previously, we had shown that glutamate receptor activation reversibly inhibited O-2A…
  4. K+ channels are a most diverse class of ion channels in the plasma membrane and are distributed widely throughout a variety of cells including cancer cells. Evidence has been accumulating from fundamental studies indicating that tumour cells possess…
  5. Organization of proteins into complexes is crucial for many cellular functions. However, most proteomic approaches primarily detect protein interactions for soluble proteins but are less suitable for membrane-associated complexes. Here we describe a…
  6. Vascular K+ channel openers such as cromakalim, nicorandil, and pinacidil potently stimulate 86Rb+ efflux from slices of substantia nigra. This 86Rb+ efflux is blocked by antidiabetic sulfonylureas, which are known to be potent and specific blockers…
  7. BACKGROUND: Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K+ channel modulators regulate ENaC activity in normal lungs, the therapeutical…
  8. Hyperpolarization-activated, cyclic nucleotide sensitive (HCN) channels underlie the pacemaker current I(f), which plays an essential role in spontaneous cardiac activity. HCN channel subunits (HCN1-4) are believed to be modulated by additional…
  9. The voltage-gated Kv1.3 channel and the Ca2+-activated IKCa1 K+ channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from…
  10. Acidification of the cytoplasm of Ehrlich ascites carcinoma cells to pH 6.3 arrests DNA synthesis in these cells. Such an effect can be achieved by incubating the cells at pH 6.2 or by adding low concentrations of the K+/H+ antiporter, the…
  11. Microscopic molecular dynamics free energy perturbation calculations of the K+/Na+ selectivity in the KcsA potassium channel, based on its experimental three-dimensional structure, are reported. The relative binding free energies for K+ and Na+ in…
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