The current medical therapy used in Crohns disease and ulcerative colitis comprises drugs that interfere with immune response and therefore caution is needed for infectious side effects, and where possible, strategies to prevent their occurrence…
Papers in Pharmacy
Pharmacy papers in Medicine, V
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Francisella tularensis is the etiologic agent of tularemia, a severe debilitating disease of humans and animals. The low infectious dose of F. tularensis in humans and the relative ease of culture are probably the properties which originally…
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The history of infectious diseases together with the evidence of emerging and reemerging infections underscores the need for new vaccines and the obstacles to producing them. Vaccine adjuvants are usually thought of as agents that increase the…
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All vaccines are susceptible to damage by elevated temperatures and many are also damaged by freezing. The distribution, storage, and use of vaccines therefore present challenges that could be reduced by enhanced thermostability, with resulting…
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Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects. Rodent models have…
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BACKGROUND: A malaria vaccine is needed because of the heavy burden of mortality and morbidity due to this disease. This review describes the results of trials of blood (asexual)-stage vaccines. Several are under development, but only one (MSP/RESA,…
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VADAR (Volume Area Dihedral Angle Reporter) is a comprehensive web server for quantitative protein structure evaluation. It accepts Protein Data Bank (PDB) formatted files or PDB accession numbers as input and calculates, identifies, graphs, reports…
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Insomnia affects approximately one-third of the adult population and contributes to increased rates of absenteeism, health care use, and social disability. Extracts of the roots of valerian (Valeriana officinalis) are widely used for inducing sleep…
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Validation of the work stress scale. The objective of this study was to develop and to validate a general instrument to evaluate occupational stress, easily administered, used in different work environments and for a variety of occupations. The Work…
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A highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has been developed to determine rasagiline in human plasma. The analytical method utilized liquid-liquid extraction of plasma with…
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The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for zidovudine (3'-azido-3'-deoxythymidine) after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis and thermal stress…
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Antibiotic-loaded polymeric bone cement is used in orthopedic surgery to deliver local high concentrations of antibiotics to the tissues. The precise mechanism by which antibiotic is released from the polymeric matrix is still not very well known.…
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The MM-PBSA approach has become a popular method for calculating binding affinities of biomolecular complexes. Published application examples focus on small test sets and few proteins and, hence, are of limited relevance in assessing the general…
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Objective: Adverse events are poor health outcomes caused by medical care. Measuring them is necessary for quality improvements, but current detection methods are inadequate. We performed this study to validate a previously derived method of adverse…
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Background: The objective of this study was to develop and psychometrically evaluate a general measure of patients' satisfaction with medication, the Treatment Satisfaction Questionnaire for Medication (TSQM). Methods: The content and format of 55…
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PURPOSE: To validate a new fiber electrode prototype for clinical electroretinography (ERG). METHODS: A recently developed prototype of a disposable reference-coupled fiber electrode (patent pending Brazilian Institute of Industrial Property…
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BACKGROUND: Bowel preparation quality scales are used to document the superiority of one preparation regime vs. another. The validity and reliability of these scales are not routinely stated in reports of studies in which the scales are used. A new…
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Peptide mapping is a key analytical method for studying the primary structure of proteins. The sensitivity of the peptide map to even the smallest change in the covalent structure of the protein makes it a valuable 'finger-print' for identity…
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There has been a need for a brief assessment tool for providers who treat chronic pain patients to determine potential risk of abuse when prescribed opioids for pain. The purpose of this study was to develop and begin the validation of a…
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In order to validate the use of urea as an internal reference for the calibration of microdialysis catheters, both subcutaneous and muscle measurements were taken in 11 healthy volunteers. The equilibration calibration of urea, glucose and lactate,…
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