We tested the hypothesis that single nucleotide polymorphisms (SNPs) within genes of the NF-κB pathway are associated with altered clinical outcome of septic shock patients. We genotyped 59 SNPs in the NF-κB pathway in a discovery cohort of septic…
Papers in Biomedical Physics
Biomedical Physics papers in Physics, A
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A major design problem concerning high-frequency broad-band ultrasound imaging systems is caused by the strong dispersive attenuation of the tissue, which gives rise to images with inhomogeneous resolution and poor signal to noise ratio (SNR). To…
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The interaction of calmodulin with D600 (a methoxy derivative of verapamil), trifluoperazine and some other drugs was studied by 113Cd and 1H NMR. All four cation binding sites of calmodulin were found to be affected by the binding of the drugs to…
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A 128-channel receive-only array coil is described and tested for cardiac imaging at 3T. The coil is closely contoured to the body with a "clam-shell" geometry with 68 posterior and 60 anterior elements, each 75 mm in diameter, and arranged in a…
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Electrical impedance tomography (EIT) is a new functional imaging technique. This paper presents the development of a new electrical impedance tomography system with 128 electrodes for impedance change detection and 3D imaging of the human thorax.…
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A CMOS sensor array for monitoring neural signals of living cells with 128 /spl times/ 128 pixels in a 1 mm/sup 2/ area is described. A standard 0.5 /spl mu/m, 5 V CMOS process extended by top electrodes covered by a relatively thin bio-compatible…
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A new head coil with 16 channels has been designed to improve the SNR in the center of the brain and provide general parallel imaging capability.
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Volume-array coils offer increased signal-to-noise ratio (SNR) over standard volume coils near the array elements while preserving the SNR at the center of the volume. As the number of array elements is increased, the SNR advantage as well as the…
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OBJECTIVE: To present oncological results with intermittent androgen deprivation (IAD) in a single center. METHODS: Between 1992 and 2008, 566 patients with prostate cancer (PC) were selected for a non-randomized study of IAD. Two hundred and…
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Several competing technologies continue to advance the field of terahertz science; of particular importance has been the development of a terahertz semiconductor quantum cascade laser (QCL), which is arguably the only solid-state terahertz source…
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This report describes a noninvasive 1H-NMR method for measuring absolute temperatures (+/- 0.2 degrees C) in biological samples and, in particular, in cell culture perfusion systems, utilizing the linear temperature dependence of the water chemical…
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Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system. We have fractionated mitotic Xenopus egg extracts to identify components required for this process. We find that UBC4 and at least one other…
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Hyperpolarized 3He gas MRI has a serious potential for assessing pulmonary functions. Due to the fact that the non-equilibrium of the gas results in a steady depletion of the signal level over the course of the excitations, the signal-tonoise ratio…
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A 256-element phased array has been designed, constructed, and tested for ablative treatment of large focal volumes of deep seated tissue. The array was constructed from a 1.1-MHz, 1-3 composite piezoelectric spherical shell with a 10-cm radius of…
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The transmissible spongiform encephalopathies (TSEs) such as endemic sheep scrapie, sporadic human Creutzfeldt-Jakob disease (CJD), and epidemic bovine spongiform encephalopathy (BSE) may all be caused by a unique class of "slow" viruses. This…
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This paper presents model-based information-theoretic methods to quantify the complexity of tumor microvasculature, taking into account shape, textural, and structural irregularities. The proposed techniques are completely automated, and are…
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We demonstrate a 2-D artificial dielectric medium suitable for the terahertz region by exploiting the characteristic frequency dependence in the phase velocity of the lowest order transverse-electric (TE1) mode of the parallel-plate waveguide…
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An analysis is made of a two-dimensional array of diodes that can be used for measuring dose generated in a plane by a radiation beam. This measuring device is the MapCHECK Model 1175 (Sun Nuclear, Melbourne, FL). This device has 445 N-type diodes…
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We describe a MATLAB implementation of a 2D wave solver capable of simulating the linear and nonlinear propagation of ultrasonic waves through an attenuating medium modeled as a 2D spatial grid, the acoustic properties of which can be arbitrarily…
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A 2D optical ultrasound receive array has been investigated. The transduction mechanism is based upon the detection of acoustically-induced changes in the optical thickness of a thin polymer film acting as a Fabry Perot interferometer (FPI). A…
Papers in associated sub-disciplines
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