11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
Bioorganic & Medicinal Chemistry (2008)
- PubMed: 18771930
Available from linkinghub.elsevier.com
or
Abstract
Several 11-substituted benzoiphenanthridine derivatives were synthesized, and their TOP1-targeting activity and cytotoxicity were assessed. Comparative data indicate that TOP1-targeting was often the primary molecular target associated with their cytotoxicity. Several 11-aminoalkyl derivatives, 11-aminocarboxy derivatives as well as the 11-(2-dimethylamino)ethylcarboxamide of 2,3-dimethoxy-8,9-methylenedioxybenzoiphenanthridine were synthesized and did exhibit considerable cytotoxicity with IC(50) values ranging from 20 to 120 nM in the human lymphoblast tumor cell line RPMI8402.
Sign up today - FREE
Mendeley saves you time finding and organizing research. Learn more
- All your research in one place
- Add and import papers easily
- Access it anywhere, anytime
Start using Mendeley in seconds!
Readership Statistics
3 Readers on Mendeley
by Discipline
33% Chemistry
by Academic Status
33% Student (Bachelor)
33% Post Doc
33% Ph.D. Student
by Country
33% Japan
33% Brazil