Transport of the carcinogen benzo[a]pyrene in apical membrane vesicles (AMV) from normal human intestine, was investigated. Benzo[a]pyrene transport was found in AMV throughout the small intestine, but was greatest in colon. Evidence suggesting involvement of P-Glycoprotein (P-Gp), included (1) comparable transport of P-Gp substrate doxorubicin, (2) transport stimulation by ATP and (3) transport suppression by the P-Gp inhibitor, verapamil. © 1994.
CITATION STYLE
Penny, J. I., & Campbell, F. C. (1994). Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium. BBA - Molecular Basis of Disease, 1226(2), 232–236. https://doi.org/10.1016/0925-4439(94)90034-5
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