AdipoQ polymorphisms are associated with type 2 diabetes mellitus: A meta-analysis study

Abstract

Objective: Adiponectin (AdipoQ) plays an important role in the pathogenesis of diabetes mellitus and is considered as an important candidate gene for type 2 diabetes mellitus (T2DM). So far, there have been many studies to investigate the association between the adiponectin polymorphisms and T2DM risk. However, the results are conflicting. To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A>G (rs16861194), -11391G>A (rs17300539), -11377C>G (rs266729), +45T>G (rs2241766) and +276G>T (rs1501299)], and T2DM risk. Methods: The fixed and random-effects model should be used to assess the summary odds ratios (ORs) of each study. ORs with 95% confidence intervals (CIs) were used to evaluate the strength of association. On the basis of the included criteria, we selected 39 papers, among which eight for -11426A>G, 14 for -11391G>A, 21 for -11377C>G, 28 for +45T>G and 24 for +276G>T. Sensitivity analyses were conducted to assess the stability of the results. Both Begg's funnel plots and Egger's test are commonly used to evaluate publication bias. Results: Overall, we found that individuals with the -11426G allele had a 0.15-fold significantly increased T2DM risk (additive model: 1.15, 1.04-1.27, 0.222). In the stratified analyses, we found that the -11426A>G, -11391G>A and -11377C>G polymorphisms could increase T2DM risk in European populations in the additive model. For Asian populations, we found that the -11377C>G polymorphism also could elevate T2DM risk. Conclusions: Our results suggested that the adiponectin -11426A>G polymorphism could contribute to the T2DM risk. © 2013 John Wiley & Sons, Ltd.