Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression. © 2009 Movement Disorder Society.
CITATION STYLE
Rajput, A., Vilariño-Güell, C., Rajput, M. L., Ross, O. A., Soto-Ortolaza, A. I., Lincoln, S. J., … Rajput, A. (2009). Alpha-synuclein polymorphisms are associated with Parkinson’s disease in a Saskatchewan population. Movement Disorders, 24(16), 2411–2414. https://doi.org/10.1002/mds.22795
Mendeley helps you to discover research relevant for your work.