Analysis of adiponectin gene polymorphisms in Chinese population with systemic lupus erythematosus

Abstract

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Adiponectin is an adipocyte-derived cytokine with anti-inflammatory, antidiabetic, and antiatherogenic properties. No study has reported on the association between adiponectin (ADIPOQ) gene and SLE. Our aim is to investigate the association between single-nucleotide polymorphisms in ADIPOQ gene and SLE. We examined 179 SLE patients and 237 age-and gender-matched controls from Sichuan province in China. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. Results show that there was no significant difference in the allele frequencies of rs1501299 (P =.311, OR = 1.17, 95 CI: 0.86-1.59) and rs2241766 (P =.929, OR = 0.99, 95 CI: 0.74-1.33) in ADIPOQ gene between SLE patients and controls. The same results were seen in their genotypes (P