Antifungal susceptibility of emerging dimorphic pathogens in the family Ajellomycetaceae

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Abstract

The in vitro susceptibilities of 24 molecularly identified dimorphic fungi belonging to the genera Adiaspiromyces, Blastomyces, and Emergomyces within the family Ajellomycetaceae were tested against 8 standard antifungal agents using CLSI document M38-A2. Amphotericin B and posaconazole had the lowest geometric mean MICs (<0.05 μg/ml) followed by itraconazole (<0.07 μg/ml), voriconazole (<0.15 μg/ml), and isavuconazole (<0.42 μg/ml) while fluconazole was not active. Micafungin demonstrated good in vitro antifungal activity against Emergomyces (geometric mean minimum effective concentration [GM MEC] 0.1 μg/ml) and Blastomyces (GM MEC <0.017 μg/ml).

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Dukik, K., Al-Hatmi, A. M. S., Curfs-Breuker, I., Faro, D., De Hoog, S., & Meis, J. F. (2018). Antifungal susceptibility of emerging dimorphic pathogens in the family Ajellomycetaceae. Antimicrobial Agents and Chemotherapy, 62(1). https://doi.org/10.1128/AAC.01886-17

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