The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a protective effect on heat-induced erythrocyte lysis at concentrations of 25, 50 and 100 μg/ml. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB). It may be inferred that the ethanol extract is effective against both exudative-proliferative and chronic phases of inflammation. © 1995.
CITATION STYLE
Perez, R. M., Perez, S., Zavala, M. A., & Salazar, M. (1995). Anti-inflammatory activity of the bark of Hippocratea excelsa. Journal of Ethnopharmacology, 47(2), 85–90. https://doi.org/10.1016/0378-8741(95)01257-E
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