Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians

Abstract

Objective The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. Methods A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma. Results Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Metaanalysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR) = 2.257, 95 % confidence interval (CI) = 1.577-3.228, p = 8.42 × 10-7]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR = 2.683, 95 % CI = 1.799-4.001, p = 1.31 × 10-7), and stratification by age indicated an association between it and asthma in adults (OR = 1.895, 95 % CI = 1.005-3.573, p = 0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms. Conclusions This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no associationwas found between theADAM33 T2 and ST+7 polymorphisms and asthma susceptibility. © 2012 Springer Basel AG.