Abstract
KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+ AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
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Tavira, B., Coto, E., Torres, A., Diáz-Corte, C., Diáz-Molina, B., Ortega, F., … Simoes Dos Santos, L. (2012). Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with tacrolimus. Molecular Genetics and Metabolism, 105(3), 525–527. https://doi.org/10.1016/j.ymgme.2011.12.020
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