Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients

Abstract

Objective: To investigate whether the polymorphism of rs10260404 in DPP6 gene in Chinese Han origin is associated with sporadic amyotrophic lateral sclerosis (SALS). Methods: The genomic DNA was extracted from the leukocytes of whole blood samples in 58 Chinese Han patients with SALS and 52 healthy controls. The asymmetric PCR was processed in the presence of an unlabeled probe that contained the rs10260404 locus. The product was genotyped on light scanner and some was confirmed with sequencing. Results: Two single nucleotide polymorphism, rs10260404 that was reportedly consistently strongly associated with susceptibility to SALS in different populations of European and American ancestry, rs10260404 were genotyped, but not strongly associated with ALS in Chinese patients (SALS: C: 12.94%, T: 87.06%; health controls: C: 10.58%, T: 89.43%; χ 2 = 0.29, OR = 1.256, 95% CI 0.549-2.872, P > 0.05). Conclusion The rs10260404 is not associated with ALS susceptibility in Chinese people. © 2009 by the Chinese Medical Association.