Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance

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Abstract

In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues. Copyright © 2006 CINP.

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Reuter, M., Kuepper, Y., & Hennig, J. (2007). Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. International Journal of Neuropsychopharmacology, 10(3), 401–404. https://doi.org/10.1017/S1461145706007073

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