Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

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Abstract

AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed. © 2011 Baishideng. All rights reserved.

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Guo, Y., Fang, J., Liu, Y., Sheng, H. H., Zhang, X. Y., Chai, H. N., … Gao, H. J. (2011). Association between polymorphism rs6983267 and gastric cancer risk in Chinese population. World Journal of Gastroenterology, 17(13), 1759–1765. https://doi.org/10.3748/wjg.v17.i13.1759

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