Association between single-nucleotide polymorphisms in pre-mirnas and the risk of asthma in a Chinese population

30Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 asthma patients and 540 controls using polymerase chain reaction-restriction fragment length polymorphism methodology and DNA-sequencing. There were significant differences in the genotype and allelic distribution of rs2910164G/C and rs2292832C/T polymorphisms among cases and controls. The CC genotype and C allele of rs2910164G/C were significantly associated with a decreased risk of asthma (CC vs. GG, odds ratio [OR]=0.51, 95% confidence interval [CI]: 0.31-0.82; C vs. G, OR=0.74, 95% CI: 0.59-0.93). Similarly, the TT genotype and T allele of rs2292832C/T were significantly associated with a decreased risk of asthma (TT vs. CC, OR=0.56, 95% CI: 0.33-0.95; T vs. C, OR=0.71, 95% CI: 0.53-0.95). However, no significant association between the other two polymorphisms (i.e., rs11614913C/T and rs3746444C/T) and the risk of asthma was observed. Our data indicate that rs2910164G/C and rs2292832C/T may play a role in the development of asthma. © 2011, Mary Ann Liebert, Inc.

Cite

CITATION STYLE

APA

Su, X. W., Yang, Y., Lv, M. L., Li, L. J., Dong, W., Miao-Liao, … Li, Y. B. (2011). Association between single-nucleotide polymorphisms in pre-mirnas and the risk of asthma in a Chinese population. DNA and Cell Biology, 30(11), 919–923. https://doi.org/10.1089/dna.2010.1164

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free