The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis

Abstract

Aim: To assess the relationship of the Interleukin-10 (IL-10)-1082G/A (rs1800896),-819C/T (rs1800871) and-592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. Methods: Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and Ulcerative colitis (UC) were selected from electronic databases. A total of 17 studies including 4132 cases and 5109 controls were included in this meta-analysis which detected whether-1082G/A,-819C/T and-592C/A polymorphism were associated with CD or UC susceptibility. Result: The IL-10-819C/T and-519C/A variant allele observed a significant association with UC (OR 1.16, 95%CI 1.03-1.31 and OR 1.19, 95%CI 1.03-1.38) not CD while there is no significant association between-1082G/A and UC or CD. Conclusion: The IL-10-819C/T and-592C/A polymorphisms contribute to susceptibility to UC, but IL-10-1082G/A polymorphism neither associated with CD nor UC. © 2014 Informa UK Ltd.