Association between various rs501120 genotypes and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome

Abstract

Objective: To assess the association between single nucleotide polymorphism rs501120 and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome (ACS). Methods: Nine hundred and two patients with diabetes complicated with acute coronary syndrome were enrolled. The genotype of rs501120 was determined with TaqMan-MGB probes. Two hundred and five cases of TT genotype, 205 age-and sex-frequency-matched cases of TC genotype and 205 age- and sex-frequency-matched cases of CC genotype were chosen and followed up for 3 years. Clinical data and re-occurrences of ACS were recorded. Results: Patients with TT genotype had a significantly higher incidence of recurrence of ACS than those with CC genotype (TT vs. CC: OR 1.7,95%CI 1. 1-2. 7, P = 0.02). And the significance has remained even after adjusting for conventional risk factors by logistic regression (OR 1.6, 95%CI 1.05-3. 6, P = 0.03). Patients with TT genotype had a significantly higher incidence of myocardial infarction than those with CC genotype(TT vs. CC: OR 1. 9, 95%CI 1.2-3. 2, P = 0.007). Conclusion: Our results has suggested an association between the rs501120 polymorphism and progress of unstable coronary atherosclerotic plaque.