A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD. © 2012 John Wiley & Sons A/S.
CITATION STYLE
Zhao, Y., Gopalai, A. A., Ahmad-Annuar, A., Teng, E. W. L., Prakash, K. M., Tan, L. C. S., … Tan, E. K. (2013). Association of HLA locus variant in parkinson’s disease. Clinical Genetics, 84(5), 501–504. https://doi.org/10.1111/cge.12024
Mendeley helps you to discover research relevant for your work.