Background: We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC). Methods: Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5′ URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (http://bioinfo.iconcologia. net/SNPstats), Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea). Results: The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%). Conclusions: Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC. © 2013 Elsevier Inc. All rights reserved.
CITATION STYLE
Eun, Y. G., Kim, S. K., Chung, J. H., & Kwon, K. H. (2013). Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer. American Journal of Surgery, 205(6), 631–635. https://doi.org/10.1016/j.amjsurg.2012.05.035
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