Abstract
Objective: To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia. Methods: Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay. Results: One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease. Conclusion: Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
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Wang, J., Ma, X. H., Xiang, B., Wu, J. Y., Wang, Y. C., Deng, W., … Li, T. (2012). Association study of NOS1 gene polymorphisms and schizophrenia. Chinese Journal of Medical Genetics, 29(4), 459–463. https://doi.org/10.3760/cma.j.issn.1003-9406.2012.04.018
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