Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: A meta-analysis

Abstract

Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95% confidence interval [CI].=.0.565-0.697, p.