Identification of host genetic determinants of measles vaccine-induced immunity can be used to design better vaccines and ultimately predict immune responses to vaccination.We performed a comprehensive candidate gene association study across 801 genetic markers in 56 cytokine/cytokine receptor genes, in a racially diverse cohort of 745 schoolchildren after two doses of MMR vaccine. Using linear regression methodologies we examined associations between SNPs/haplotypes and measles virus-specific immunity.Forty-eight significant SNP associations with variations in neutralizing antibodies and measles-specific IFNγ Elispot responses were identified (p
CITATION STYLE
Haralambieva, I. H., Ovsyannikova, I. G., Kennedy, R. B., Vierkant, R. A., Pankratz, V. S., Jacobson, R. M., & Poland, G. A. (2011). Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination. Vaccine, 29(45), 7883–7895. https://doi.org/10.1016/j.vaccine.2011.08.083
Mendeley helps you to discover research relevant for your work.