Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women (ESR1 and ESR2 polymorphisms and metabolic syndrome) Alessandra

  • Alessandra C Goulart, Robert YL Zee, Aruna Pradhan A
N/ACitations
Citations of this article
1Readers
Mendeley users who have this article in their library.

Abstract

Abstract Background—Genetic variation of the estrogen receptor alpha (ESR1) and beta (ESR2) has been associated with components of the metabolic syndrome (MetS). Methods—The relationships of two ESR1 (rs2234693 and rs9340799) and three ESR2 (rs1271572, rs1256049 and rs4986938) polymorphisms with the MetS were examined in 532 Caucasian female participants (median age 63.1 years) in the Women’s Health Study. Most women (99.1%) were postmenopausal. The associations between ESR1 and ESR2 genotypes and haplotypes with the MetS were evaluated. Effect modification by hormone therapy was also assessed. Results—Genotype and haplotype distributions were similar between women with and without MetS. We found no consistent associations between the genotypes and haplotypes tested and the MetS, or its components, in logistic regression models. No effect modification by hormone therapy use was noted. Conclusions—No association between these genetic variants in ESR1 and ESR2 and the MetS was observed among these Caucasian women. Further investigation regarding the potential involvement of estrogen receptor genes and the MetS may be warranted in other ethnic groups.

Cite

CITATION STYLE

APA

Alessandra C Goulart, Robert YL Zee, Aruna Pradhan, and K. M. R. (2010). Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women (ESR1 and ESR2 polymorphisms and metabolic syndrome) Alessandra. NIH Public Access, 7(2), 111–118.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free