Background: Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease. Methodology/Principal Findings: Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein. Conclusions: Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis. © 2011 Salajegheh et al.
CITATION STYLE
Salajegheh, M., Lam, T., & Greenberg, S. A. (2011). Autoantibodies against a 43 kDa muscle protein in inclusion body myositis. PLoS ONE, 6(5). https://doi.org/10.1371/journal.pone.0020266
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