OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) of the brain-derived neurotrophic factor (BDNF) that have been associated with bipolar illness are associated with physiological dysfunction. Methods: Lymphoblastoid cell lines (n=30) obtained from bipolar I individuals carrying zero, one, or two copies of a BDNF SNP associated with bipolar illness (rs12273363) were utilized. Results: Proapoptotic stressors of serum deprivation alone, or serum deprivation combined with the sodium ionophore, monensin, did not alter intracellular proBDNF. Monensin treatment increased mature-BDNF (mBDNF) protein levels (P<0.05). There were no differences related to the presence of SNP or copy number. Conclusion: rs12273363 does not appear to have functional consequences that would involve its role in bipolar illness. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
CITATION STYLE
Gao, Y., Galante, M., El-Mallakh, J., Nurnberger, J. I., Delamere, N. A., Lei, Z., & El-Mallakh, R. S. (2012). BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorder. Psychiatric Genetics, 22(5), 253–255. https://doi.org/10.1097/YPG.0b013e328353ae66
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