Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process. © 2011 Boes et al; licensee BioMed Central Ltd.
CITATION STYLE
Boes, A. D., Grafft, A. H., Joshi, C., Chuang, N. A., Nopoulos, P., & Anderson, S. W. (2011). Behavioral effects of congenital ventromedial prefrontal cortex malformation. BMC Neurology, 11. https://doi.org/10.1186/1471-2377-11-151
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