Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P interaction = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway. Copyright © 2008 American Association for Cancer Research.
CITATION STYLE
Bhatti, P., Doody, M. M., Alexander, B. H., Yuenger, J., Simon, S. L., Weinstock, R. M., … Sigurdson, A. J. (2008). Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. Cancer Epidemiology Biomarkers and Prevention, 17(8), 2007–2011. https://doi.org/10.1158/1055-9965.EPI-08-0300
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