A case of immune-mediated encephalitis related to daclizumab therapy

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Abstract

This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease-modifying therapy in relapsing-remitting multiple sclerosis. The withdrawal of this therapy was prompted by concerns over 12 cases of serious immune-mediated adverse reactions in the central nervous system. We report an additional case, including clinical data and results of neuroimaging, cerebrospinal fluid (CSF) examination and brain biopsy.

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Devlin, M., Swayne, A., Newman, M., O’Gorman, C., Brown, H., Ong, B., … Blum, S. (2019). A case of immune-mediated encephalitis related to daclizumab therapy. Multiple Sclerosis Journal, 25(5), 750–753. https://doi.org/10.1177/1352458518792403

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