Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO. Objectives: The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese. Methods: Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing. Results: The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS. Conclusions: CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.
CITATION STYLE
C., L., G., W., H., L., Y., L., J., L., Y., D., & X., H. (2012). CD226 Gly307Ser association with neuromyelitis optica in southern Han Chinese. Canadian Journal of Neurological Sciences. X. Hu, Multiple Sclerosis Center, Department of Neurology, Third Affiliated Hospital of Sun Yat-Sen University, No.600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. E-mail: huxueqiangzssy@yahoo.com.cn: Canadian Journal of Neurological Sciences (Nr.709 -7015 MacLeod Trail S.W., Calgary AB T2H 2K6, Canada). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=2012380617
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