We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
CITATION STYLE
Dorta, G., Siebenmann, R., Fröhli, P., Freytag, P., & Koelz, H. R. (1989). [Clozapine-induced cholestatic jaundice: a case report]. Zeitschrift Fur Gastroenterologie, 27(7), 388–90. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2773535
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