CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs

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Abstract

The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined. © 2012 Kos et al.

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Kos, M., van den Brink, D., Snijders, T. M., Rijpkema, M., Franke, B., Fernandez, G., & Hagoort, P. (2012). CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs. PLoS ONE, 7(10). https://doi.org/10.1371/journal.pone.0046995

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