A common genetic variant of BDNF is assocated with type 2 diabetes in chinese han population

Abstract

Aim: Recently, several genome wide association studies have identified many loci associated with obesity or body mass index(BMI), of which Fto was also consistently confirmed to affect genetic suceptibility to type 2 diabetes in the diferent population,although the association dispeared in European after adjustment for BMI.In contrast, several BMI related genetic loci such as BNDF,GNPDA2 and Fto were reported to be associated with type 2 diabetes in Japanese independent of BMI effect.Our study aim to evaluate the contribution of NEGR,GNPDA2 and BDNF genetic loci to type 2 diabetes in Chinese Han population. Method: 1221 Chinese subjects with normal 75g oral glucose tolerance recruited from community near Peking University People's Hospital and 1069 Chinese patients with type 2 diabetes from outpatients of Peking University People's Hospital were include into this case control study. Three single nuleotide polymorphism including NEGR-rs2815752, GNPDA2-rs10938397 and BDNF-rs4074134 were genotyped. The odd ratios(OR) for minor allele and 95% confidence interval were calculated by logistic regression with adjustment for gender, age and BMI. Results: An association of BDNF-rs4074134, but not NEGR-rs2815752 and GNPDA2-rs10938397, with type 2 diabetes in Chinese was confirmed with OR 0.88(95% CI 0.77-0.99),p=0.046 independent of gender,age and BMI.In non diabetes controls, a linear regression showed BDNF-rs4074134 A allele was negatively related to BMI after adjusting gender and age. Conclusion: Our study suggested BDNF-rs4074134 was associated with type 2 diabetes in Chinese Han population in Beijing ,China ,and this SNP also had an effect on BMI.