Objectives/Hypothesis: Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC. Study Design: Case-control study. Methods: We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odds ratios and compute P values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method. Results: We did not find a significant association between rs1562430, rs1447295, or rs6983267 and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P =.003, and 12 other SNPs were associated with PTC risk at P
CITATION STYLE
Neta, G., Yu, C. L., Brenner, A., Gu, F., Hutchinson, A., Pfeiffer, R., … Sigurdson, A. J. (2012). Common genetic variants in the 8q24 region and risk of papillary thyroid cancer. Laryngoscope, 122(5), 1040–1042. https://doi.org/10.1002/lary.23209
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