A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
CITATION STYLE
An, P., Winkler, C., Guan, L., O’Brien, S. J., Zeng, Z., Yu, Y., … Qu, Q. (2011). A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. Journal of Infectious Diseases, 203(7), 943–947. https://doi.org/10.1093/infdis/jiq154
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