After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.
CITATION STYLE
Thye, T., Owusu-Dabo, E., Vannberg, F. O., Van Crevel, R., Curtis, J., Sahiratmadja, E., … Meyer, C. G. (2012). Common variants at 11p13 are associated with susceptibility to tuberculosis. Nature Genetics, 44(3), 257–259. https://doi.org/10.1038/ng.1080
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