Common variation in the LRRK2 gene is a risk factor for Parkinson's disease

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Abstract

Background: Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear. Methods: We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P

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Mata, I. F., Checkoway, H., Hutter, C. M., Samii, A., Roberts, J. W., Kim, H. M., … Zabetian, C. P. (2012). Common variation in the LRRK2 gene is a risk factor for Parkinson’s disease. Movement Disorders, 27(14), 1823–1826. https://doi.org/10.1002/mds.25226

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