More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of ,27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P,5610
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Lill, C. M., Roehr, J. T., Mcqueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B.-M. M., … Bertram, L. (2012). Comprehensive Research Synopsis and Systematic Meta- Analyses in Parkinson’s Disease Genetics: The PDGene Database , The Wellcome Trust Case Control Consortium 2 (WTCCC2). PLoS Genetics, 8(3). Retrieved from http://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002548&type=printable
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