Computational neurogenetic modeling: Integration of spiking neural networks, gene networks, and signal processing techniques

Abstract

The paper presents a theory and a new generic computational model of a biologically plausible artificial neural network (ANN), the dynamics of which is influenced by the dynamics of internal gene regulatory network (CRN). We call this model a "computational neurogenetic model" (CNGM) and this new area of research Computational Neurogenetics. We aim at developing a novel computational modeling paradigm that can potentially bring original insights into how genes and their interactions influence the function of brain neural networks in normal and diseased states. In the proposed model, FFT and spectral characteristics of the ANN output are analyzed and compared with the brain EEG signal. The model includes a large set of biologically plausible parameters and interactions related to genes/proteins and spiking neuronal activities. These parameters are optimized, based on targeted EEG data, using genetic algorithm (GA). Open questions and future directions are outlined. © Springer-Verlag Berlin Heidelberg 2005.