A noninvasive procedure to detect muscle weakness in the mdx mouse
Intercultural Education (1996)
- ISSN: 14675986
- DOI: 10.1080/0952391960070302
- PubMed: 2366821
Available from www.informaworld.com
or
Abstract
The forward pulling tension exerted by individual mice was measured nearly isometrically in a simple apparatus designed to determine whole body tension (WBT). WBT determinations on control (C57Bl10/SnJ) and experimental (C57Bl10-mdx) mice indicate a muscle weakness which lasts throughout the lifespan of mdx mice. Direct muscle stimulation experiments in vivo also showed significant decreases in peak twitch and tetanic tensions in adult mdx muscle with no obvious alterations in twitch time course or in twitch: tetanus ratios. We suggest that the noninvasive WBT procedure may be used to partially assess various therapies on this murine model of Duchenne muscular dystrophy
Sign up today - FREE
Mendeley saves you time finding and organizing research. Learn more
- All your research in one place
- Add and import papers easily
- Access it anywhere, anytime
Start using Mendeley in seconds!
Readership Statistics
1 Reader on Mendeley
by Discipline
100% Biological Sciences
by Academic Status
100% Professor
by Country
100% United States