To evaluate the potential for gene-gene interaction effects in sporadic breast cancer (BC) risk, we studied combinations of the fibroblast growth factor receptor 2 (FGFR2) rs1219648 and tumor protein 53 (TP53) rs1042522, rs1625895, and rs17878362 polymorphisms in BC patients (n=388) and healthy persons (n=275). In addition to a single-locus effect manifested by the association of FGFR2 rs1219648 and TP53 rs1042522 polymorphisms with high BC risk, depending on menopause status (0.001
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Cherdyntseva, N. V., Denisov, E. V., Litviakov, N. V., Maksimov, V. N., Malinovskaya, E. A., Babyshkina, N. N., … Choinzonov, E. L. (2012). Crosstalk between the FGFR2 and TP53 genes in breast cancer: Data from an association study and epistatic interaction analysis. DNA and Cell Biology, 31(3), 305–315. https://doi.org/10.1089/dna.2011.1351
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