The first example of the Büchner-Curtius-Schlotterbeck reaction of cyclic ketones with a stabilized cyclic diazo compound partner is described. The approach towards spirocyclic scaffolds has been exemplified with readily available ∝-diazo-γ-butyrolactone. The reaction proved to be viable with BF3∙OEt2 as the preferred catalyst and displayed substantial sensitivity to the size of the cyclic ketone.
CITATION STYLE
Shershnev, I., Dar’in, D., Chuprun, S., Kantin, G., Bakulina, O., & Krasavin, M. (2019). The use of ∝-diazo-γ-butyrolactone in the Büchner-Curtius-Schlotterbeck reaction of cyclic ketones: A facile entry into spirocyclic scaffolds. Tetrahedron Letters, 60(27), 1800–1802. https://doi.org/10.1016/j.tetlet.2019.06.008
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