Diuretic and antimicrobial activity of methanolic extract of Petroselinum cripsum leaves

Abstract

Methanolic extract of Petroselinum cripsum leaves were tested for diuretic and antimicrobial activity. The diuretic activity was tested in rats at 500 and 1000 mg/Kg, orally and compared with furosemide (20mg/Kg) as the standard. The methanol extract was found to possess significant dose dependent diuretic activity. Methanol extract of leaves of Petroselinum cripsum was investigated for their in vitro antimicrobial properties by agar disc diffusion method against Gram positive bacteria Bacillus subtilis ,Staphylococcus aureus, Micrococcus luteus and Gram negative bacteria Escherichia coli Pseudomonas aureginosa and Salmonella typhi and antifungal activity against Aspergillus niger and Candida albicans. All tested microorganisms showed dose dependent susceptibility towards the methanol extracts. The antibacterial and antifungal activity of the extract and standard drugs were statistically significant. Based on the current findings it can be concluded that the plant possess potent antimicrobial and diuretic activity.