DNA minor groove binders

Abstract

DNA binding drugs form an important class of compounds which can be utilized as anticancer and antibacterial agents. We have investigated the DNA binding ability of small indole derivatives using fluorescence and molecular docking techniques. The results clearly demonstrate that small indole derivatives bind with DNA double helix showing binding affinity of 104105 per mole. All the indole derivatives were found to be binding in the minor groove of DNA. The binding was non-specific nature and dominated by van der Waals and hydro-phobic forces. The experimental and computational results were found to be in good agreement as evident by the high correlation constant values.

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