To study antibiotic efficacy, 29 patients with leptospirosis were treated in a randomized, double-blinded fashion with doxycycline, 100 mg orally twice a day, or placebo. Therapy was given for 7 days in a hospital, and patients were followed for 3 weeks afterwards. Duration of illness before therapy and severity of illness were the same in both groups. Doxycycline reduced the duration of illness by 2 days and favorably affected fever, malaise, headache, and myalgias. Treatment prevented leptospiruria and had no adverse effects. Doxycycline is effective in therapy for patients with leptospirosis.
CITATION STYLE
McClain, J. B., Ballou, W. R., Harrison, S. M., & Steinweg, D. L. (1984). Doxycycline therapy for leptospirosis. Annals of Internal Medicine, 100(5), 696–698. https://doi.org/10.7326/0003-4819-100-5-696
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